導(dǎo)師簡介

姓名：暢雪麗性別：女政治面貌：中共黨員

學(xué)歷：博士學(xué)位：博士職稱：副主任醫(yī)師

博、碩導(dǎo)師：碩導(dǎo)本崗位工作年數(shù)：10年

研究方向：神經(jīng)肌肉病

榮譽(yù)稱號：無

學(xué)術(shù)任職：中國醫(yī)師協(xié)會(huì)神經(jīng)內(nèi)科醫(yī)師分會(huì)青年工作組學(xué)組成員；山西省醫(yī)學(xué)會(huì)神經(jīng)病學(xué)分會(huì)青年委員會(huì)副主任委員；山西省醫(yī)學(xué)會(huì)神經(jīng)病學(xué)分會(huì)神經(jīng)肌肉病學(xué)組副組長

近五年承擔(dān)科研課題情況：

1.山西省科學(xué)技術(shù)廳,山西省基礎(chǔ)研究計(jì)劃, 202403021221288, NEMF調(diào)控內(nèi)質(zhì)網(wǎng)應(yīng)激參與海馬神經(jīng)發(fā)生導(dǎo)致認(rèn)知障礙的機(jī)制研究, 2025-01至2027-12, 7萬元,在研,主持

2.山西醫(yī)科大學(xué)2024年高等教育“百億工程”科技引導(dǎo)專項(xiàng)—基礎(chǔ)-臨床雙向轉(zhuǎn)化專項(xiàng)，BYJH011，NEMF調(diào)控內(nèi)質(zhì)網(wǎng)應(yīng)激參與成年海馬神經(jīng)發(fā)生導(dǎo)致認(rèn)知障礙的機(jī)制研究，20萬元，在研，主持

3.國家自然科學(xué)基金委員會(huì),青年科學(xué)基金項(xiàng)目, 82001222, NEMF參與神經(jīng)發(fā)育致神經(jīng)變性疾病發(fā)生的分子機(jī)制研究, 2021-01-01至2023-12-31, 24萬元,結(jié)題,主持

4.中華國際醫(yī)學(xué)交流基金會(huì)創(chuàng)新思維研究基金，Z-2016-20-1801，MELAS患者神經(jīng)元中PPAR/PGC-1α通路的關(guān)鍵作用及干預(yù)研究，10萬元，結(jié)題，主持

代表性論著及近五年的代表性論文（限10項(xiàng)以內(nèi)）：

1.通訊作者. Juan Wang; Rongjuan Zhao; Jing Ma; Jiangbo Qin; Huiqiu Zhang; Junhong Guo;Xueli Chang*; Wei Zhang*. Biallelic FDXR mutations induce ferroptosis in a rare mitochondrial disease with ataxia, Free Radic Biol Med, 2025, 230: 248-262.

2.通訊作者. Juan Wang; Jianhua Wang; Hanshuai Cao; Yingming Xing; Zhuoran Wang; Jing Ma; Rongjuan Zhao; Wei Zhang; Junhong Guo*;Xueli Chang*. The relationship between Ribosome-associated Quality Control and neurological disorders, The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2025, 80(4): glae304.

3.通訊作者.Feng Liang; Runyang Li; Make Yao; Jing Wang; Yunhong Li; Lijian Lei; Junhong Guo;Xueli Chang*. Deciphering Prognostic Indicators in Non-HIV Cryptococcal Meningitis: Constructing and Validating a Predictive Nomogram Model, Medical Mycology, 2024, 62(9): myae092.

4.通訊作者. Feng Liang; Runyang Li; Junhong Guo; Wei Zhang; Xueli Chang*. Assessing PET/CT's diagnostic accuracy in idiopathic inflammatory myopathies,Hell J Nucl Med, 2024; 27(1): 46-54.

5.通訊作者. Juan Wang; Rongjuan Zhao; Hanshuai Cao; Zhaoxu Yin; Jing Ma; Yingming Xing; Wei Zhang;Xueli Chang*; Junhong Guo*. A novel autosomal dominant ERLIN2 variant activates endoplasmic reticulum stress in a Chinese HSP family, Ann Clin Transl Neurol, 2023, 10(11): 2139-2148.

6.通訊作者.Wei Zhang,Jing Ma,Jiaying Shi,Shan Huang,Rongjuan Zhao,Xiaomin Pang,Juan Wang,Junhong Guo,Xueli Chang*. GGC repeat expansions in NOTCH2NLC causing a phenotype of lower motor neuron syndrome. J Neurol, 2022, 269(8):4469-4477.

7.第一作者.Xueli Chang,Zhaoxu Yin,Wei Zhang,Jiaying Shi,Chuanqiang Pu,Qiang Shi,Juan Wang,Jing Zhang,Li Yan,Wenqu Yang,Junhong Guo*. Data-independent acquisition-based quantitative proteomic analysis of m.3243A>G MELAS reveals novel potential pathogenesis and therapeutic targets. Medicine (Baltimore), 2022, 101(41):e30938.

8.通訊作者.Li Yan,Zhao-Xu Yin,Xue-Li Chang*,Rui Wang,Xiu-Min Zhang,Jun-Hong Guo. Neuromuscular junction disorders: Experimental models and pathophysiological mechanisms. Acta Neurobiol Exp (Wars), 2022;82(4):501-510.

9.第一作者.Chang X, Wu Y, Zhou J, Meng H, Zhang W, Guo J*. A meta-analysis and systematic review of Leigh syndrome: clinical manifestations, respiratory chain enzyme complex deficiency, and gene mutations. Medicine (Baltimore), 2020, 99(5): e18634.

10.通訊作者. Wen Q,Chang X*, Guo J*. A childhood?onset nemaline myopathy caused by novel heterozygote variants in the nebulin gene with literature review. Acta Neurologica Belgica, 2020,120(6):1351-1360.