導(dǎo)師簡介

姓名：徐隋意 性別：男 政治面貌：中共黨員 學(xué)歷：博士

學(xué)位：博士 職稱：主任醫(yī)師 博、碩導(dǎo)師：碩士生導(dǎo)師

本崗位工作年數(shù)：11年

研究方向：頭痛的基礎(chǔ)與臨床

榮譽稱號：三晉英才，中國卒中學(xué)會優(yōu)秀科技工作者

學(xué)術(shù)任職：

中國醫(yī)師協(xié)會神經(jīng)內(nèi)科醫(yī)師分會頭痛與感覺障礙學(xué)組委員

中國研究型醫(yī)院學(xué)會頭痛與感覺障礙專業(yè)委員會常務(wù)委員

中國卒中學(xué)會青年理事會理事

中國老年醫(yī)學(xué)學(xué)會神經(jīng)醫(yī)學(xué)委員會委員/青年副主任委員

山西省健康協(xié)會頭痛專業(yè)委員會主任委員

山西省醫(yī)師協(xié)會神經(jīng)內(nèi)科醫(yī)師分會腦與脊髓損害學(xué)組副主任委員

山西省醫(yī)學(xué)會心身醫(yī)學(xué)專業(yè)委員會神經(jīng)內(nèi)科學(xué)組副主任委員

山西省醫(yī)學(xué)會神經(jīng)病學(xué)專業(yè)委員會頭痛學(xué)組副組長

Stroke and Vascular Neurology編委（1區(qū)）

近五年承擔(dān)科研課題情況：

1. 2025年國際多中心臨床研究：一項評價Atogepant用于月經(jīng)性偏頭痛預(yù)防性治療的療效、安全性和耐受性的多中心、隨機、雙盲、安慰劑對照III期研究，分中心PI（78萬）

2. 2024年全國多中心臨床研究：中國偏頭痛治療真實世界研究，分中心PI（12萬）

3. 2023年山西省基礎(chǔ)研究計劃：低溫通過調(diào)控線粒體自噬保護OGD/R腦血管內(nèi)皮細胞的機制研究，項目編號：202303021221222（8萬）

4. 2022年山西省人社廳省級博士基金項目：HTRA1基因下調(diào)與過表達對小鼠腦微血管內(nèi)皮細胞功能影響的研究，項目編號：SD2215（5萬）

5. 2021年136興醫(yī)工程專項：急性缺血性卒中血管再通后橋接低溫灌注對線粒體質(zhì)量控制的分子機制（13萬）

代表性論著及近五年的代表性論文（限10項以內(nèi)）：

1.Sun WX, Chen TY, Song MM,et al. Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing. Frontiers in neurology 2025; DOI: 10.3389/fneur. 2025.1561000.（通訊作者）

2.Song SN, Li HJ, Liang JL, et al. Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway. Journal of integrative neuroscience 2024; 23: 201. 2024/11/30. DOI: 10.31083/j.jin2311201.（通訊作者）

3.Yang MF, Ren DX, Pan X, et al. The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review. Pain and therapy 2024 2024/05/15. DOI: 10.1007/s40122-024-00610-9.（通訊作者）

4.Zhang S, Xu S, Chen C, et al. Profile of Chinese Cluster Headache Register Individual Study (CHRIS): Clinical characteristics, diagnosis and treatment status data of 816 patients in China. Cephalalgia : an international journal of headache 2024; 44: 3331024241235193. 2024/03/19. DOI: 10.1177/03331024241235193.（共同第一作者）

5.Xu SY, Zhang Q and Li CX. Paroxysmal Sympathetic Hyperactivity After Acquired Brain Injury: An Integrative Review of Diagnostic and Management Challenges. Neurology and therapy 2024; 13: 11-20. 2023/11/10. DOI: 10.1007/s40120-023-00561-x.

6.Xu SY, Song MM, Pan X, et al. Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2023; 56: e13140. 2023/12/13. DOI: 10.1590/1414-431X2023e13140.

7.Xu SY, Li L, Sun WX, et al. Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option. Frontiers in neurology 2023; 14: 1179391. 2023/07/10. DOI: 10.3389/fneur.2023.1179391.

8.Xu SY, Li HJ, Li S, et al. Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease. International journal of general medicine 2023; 16: 1149-1162. 2023/04/06. DOI: 10.2147/ijgm.S404813.

9.Hou SJ, Zhang SX, Li Y, et al. Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy. Clinical interventions in aging 2023; 18: 1629-1639. 2023/10/09. DOI: 10.2147/cia.S429440.（通訊作者）

10.Xu SY, Song MM, Li L, et al. Adie's Pupil: A Diagnostic Challenge for the Physician. Medical science monitor: international medical journal of experimental and clinical research 2022; 28: e934657. 2022/03/20. DOI: 10.12659/msm.934657.

11.Xu SY, Wang RJ, Zhang L, et al. Basilar dolichoectasia with intermural hematoma accompanied by cerebral microbleeds and white matter hyperintensities: A case report. Medicine 2021; 100: e27022. 2021/08/21. DOI: 10.1097/md.0000000000027022.

12.Xu SY, Song MM, Liu DY, et al. Contrast-induced encephalopathy with significantly elevated levels of cerebrospinal fluid protein. British journal of neurosurgery 2021: 1-5. 2021/08/27. DOI: 10.1080/02688697.2021.1970113.

13.Xu SY, Liang JL, Li HJ, et al. Type II Alexander disease with fragile X mental retardation 1 gene mutation. Clinical neurology and neurosurgery 2021; 211: 107023. 2021/11/21. DOI: 10.1016/j.clineuro.2021.107023.

14.Xu SY, Li HJ, Huang J, et al. Migraine with Brainstem Aura Accompanied by Disorders of Consciousness. Journal of pain research 2021; 14: 1119-1127. 2021/04/29. DOI: 10.2147/jpr.S305483.

15.Xu SY, Z, M.; Wu, X. W.; Li, L.; Li, C. X. The mechanisms of limb hemiplegia after ipsilateral brain hemisphere stroke. Int J Clin Exp Med 2020; 13: 7386-7392.

16.Xu SY, Li ZX, Wu XW, et al. Frequency and Pathophysiology of Post-Seizure Todd's Paralysis. Medical science monitor: international medical journal of experimental and clinical research 2020; 26: e920751. 2020/03/07. DOI: 10.12659/msm.920751.

17.Xu SY, Li CX, Li LY, et al. Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning. BMC neurology 2020; 20: 96. 2020/03/19. DOI: 10.1186/s12883-020-01677-5.